Determination of the Proliferation and Apoptotic Index in Adrenocorticotropin-Secreting Pituitary Tumors
نویسندگان
چکیده
منابع مشابه
Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas.
Somatostatin analogs and dopamine agonists are clinically used for medical therapy of functioning pituitary tumors, such as growth hormone- and prolactin-secreting tumors, however, their effects on ACTH-secreting tumors are controversial. This study was aimed to determine whether somatostatin receptor (SSTR) subtype (1-5) and dopamine receptor type 2 (D2R) are differentially expressed in pituit...
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Prolactin secreting adenomas (prolactinomas) are the most prevalent form of pituitary tumors in humans. Prolactinomas have been linked to estrogen exposure in humans and animals. However, the mechanism by which estrogen increases mitogenesis in lactotropes, as well as other estrogen responsive cells, is not well understood. Given the complex nature of steroid hormones and their wide array of ac...
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Destruction of the thyroid gland by I's' in mice is followed by the development of TSH (thyroid stimulating hormone)-secreting pituitary tumors (5, 11, 13). These tumors can at first be grafted only on mice similarly radiothyroidectomized and not on normal animals (5) ; thus, they are initially conditioned or dependent growths. The tumor cells gain autonomy in the course of passages, as mdi cat...
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15 صفحه اولGalanin is released by adrenocorticotropin-secreting pituitary adenomas in vivo and in vitro.
Galanin, a brain-gut peptide, is also synthesized and released by the pituitary. In man, galanin-like immunoreactivity and galanin messenger RNA have been detected specifically in normal and tumoral corticotropes, but little is known about the production and release of galanin by the human pituitary. We evaluated galanin release by 5 ACTH-secreting pituitary adenomas in culture and plasma galan...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2000
ISSN: 0002-9440
DOI: 10.1016/s0002-9440(10)64725-6